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Technological Innovations

The concept of oligonucleotide therapeutics has constantly been evolving, and currently is mainly comprised of small interfering RNA (siRNA), antisense oligonucleotide (ASO), microRNA (miRNA), activation RNA(RNAa), and aptamer, with siRNA and ASO being the two major categories of oligonucleotide therapeutics. By recognizing and inhibiting target mRNA through complementary base pairing, siRNA and ASO can regulate the expression of corresponding proteins and thereby treat related diseases.  Built upon very strong technology foundation and uniquely positioned global strategy, Ribo's development pipeline of oligonucleotide therapeutics has included siRNA, ASO, and aptamer, with siRNA drugs as the major focus.

siRNA Delivery Technologies(RIBO-GalSTAR®)

Efficient and specific delivery of siRNA has been the bottleneck for the therapeutic application of siRNA. The delivery systems based on the uptake of siRNA via interaction of conjugated N-acetylgalactosamine (GalNAc) with its receptor has tremendously accelerated the siRNA drug development for the treatment of diseases associated with any gene expression in hepatocytes. GalNAc-siRNA conjugates specifically bind to the asialoglycoprotein receptor (ASGPR) on the surface of hepatocytes and trigger fast endocytosis of the siRNA. This can result in highly specific and highly durable enrichment of the siRNA in hepatocytes. Based on similar principles, additional delivery technologies are under various stages of exploration at Suzhou Ribo Life Science Co., Ltd. with the strong hope for enabling robust and versatile development of siRNA drugs for diseases related to gene expression in other organs and tissues.

Suzhou Ribo Life Science Co., Ltd´s proprietary GalNAc-based System for liver TARgeting, named RIBO-GalSTAR®,  include a unique delivery technology for delivering oligonucleotide therapeutics for various targets and indications with origin in the liver. Ribo Life Science's IP portfolios and the collaborations with other companies provide solid support for the product pipelines of the company and enable us to develop differentiated innovative drugs to address numerous unmet medical needs.

Oligonucleotide Sequence Design and High-Throughput Screening

Ribo has independently developed a computer software  to design oligonucleotide drug sequences. Taking into consideration of sequence conservation, homology, immunogenicity and potential off-target etc., this software performs a comprehensive sequence analysis against more than 50 parameters for inter-species sequence comparison and homology assessment to rapidly select high-quality siRNA sequences with desired specificity and potential activity. Ribo has also established a platform for the high-throughput screening of oligonucleotide compounds, which are able to  rapidly generate lead compounds.

RNA Therapeutics Modification for Enhanced Stability

Naked or unmodified oligonucleotides are highly susceptible to degradation, which associates with different degrees of their off-target effects and/or immunogenicity. Chemical modifications may affect oligonucleotide activities to various extent. Ribo scientists have systematically studied the mechanisms for siRNA degradation and correlated their potency with off-target effects.  Empirical rules have been established for the chemical modifications that can significantly enhance the stability of siRNA, and lower or eliminate their off-target effects, as well as potential immunogenicity. The overall properties of our drug molecules can be greatly improved through this technology.

CMC Development of Oligonucleotides

Based on extensive experience in the unique characteristics of oligonucleotides and tailored for the specific needs of drug development of oligonucleotides , we have established systematic approaches for efficient chemical modifications to enable the development of various types of oligonucleotide therapeutics across all developmental stages. Taking a holistic approach, Ribo has developed manufacturing process and studied quality of oligonucleotide drug substance and product in a systematic manner, meeting the pharmaceutical needs for discovery, preclinical study, clinical trial application and clinical study.